{"id":2081,"date":"2026-01-30T09:22:23","date_gmt":"2026-01-30T09:22:23","guid":{"rendered":"https:\/\/cumcura.be\/?p=2081"},"modified":"2026-05-25T14:31:41","modified_gmt":"2026-05-25T14:31:41","slug":"260130-1","status":"publish","type":"post","link":"https:\/\/cumcura.be\/fr\/260130-1\/","title":{"rendered":"Nouveau bras d'\u00e9tude dans l'essai rEECur avec la trabect\u00e9dine pour le sarcome d'Ewing r\u00e9cidivant"},"content":{"rendered":"

Nouveau bras d'\u00e9tude dans l'essai rEECur avec la trabect\u00e9dine pour le sarcome d'Ewing r\u00e9cidivant<\/strong><\/h4>\n
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Birmingham\/Manchester, Royaume-Uni, 21 janvier 2026<\/span><\/strong><\/em><\/div>\n<\/header>\n
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Le sarcome d'Ewing, un cancer rare des os et des tissus mous chez l'enfant et le jeune adulte, pr\u00e9sente un pronostic d\u00e9favorable en cas de rechute. La trabect\u00e9dine offre une nouvelle option th\u00e9rapeutique prometteuse.<\/span><\/strong>
<\/span>Des associations de patients se sont associ\u00e9es aux chercheurs et au fabricant de la trabect\u00e9dine pour mettre en place un nouveau bras de traitement incluant ce m\u00e9dicament dans le cadre de l'\u00e9tude rEECur, le plus vaste essai randomis\u00e9 international men\u00e9 sur le sarcome d'Ewing r\u00e9cidivant. Cette avanc\u00e9e offrira des options suppl\u00e9mentaires aux patients disposant de peu de traitements. Le lancement de ce bras de traitement est pr\u00e9vu au Royaume-Uni et \u00e0 l'international dans le courant de l'ann\u00e9e.<\/span><\/p>\n

rEECur<\/span><\/strong>\u00a0<\/span>est un essai clinique international men\u00e9 par le\u00a0<\/span><\/span>Euro Ewing Consortium (EEC)<\/span><\/strong>\u00a0<\/span>et coordonn\u00e9 par l'\u00a0<\/span><\/span>Cancer Research Clinical Trials Unit (CRCTU) van<\/span><\/strong>\u00a0<\/span>l'Universit\u00e9 de Birmingham. Sa conception flexible \u00e0 plusieurs bras permet d'\u00e9tudier diff\u00e9rents traitements au sein d'un m\u00eame essai, optimisant ainsi l'utilisation des ressources limit\u00e9es dont disposent les patients atteints de ce cancer rare.<\/span><\/p>\n

L'inclusion de la trabect\u00e9dine repose sur des donn\u00e9es prometteuses pr\u00e9sent\u00e9es lors du congr\u00e8s annuel de l'American Society of Clinical Oncology (ASCO) 2024, qui ont d\u00e9montr\u00e9 un b\u00e9n\u00e9fice clinique dans le sarcome d'Ewing. Ceci fournit une justification scientifique solide pour \u00e9valuer le m\u00e9dicament dans le cadre de l'\u00e9tude rEECur. Pour les patients, majoritairement jeunes, atteints de sarcome d'Ewing, la mise \u00e0 disposition de la trabect\u00e9dine repr\u00e9sente un espoir et une opportunit\u00e9. Le calendrier de l'essai est crucial afin d'\u00e9viter tout chevauchement avec d'autres \u00e9tudes qui pourraient n\u00e9cessiter l'acc\u00e8s au m\u00eame petit groupe de patients. Ce m\u00e9dicament offre un espoir aux patients en rechute qui auraient acc\u00e8s \u00e0 une association m\u00e9dicamenteuse potentiellement plus efficace et moins toxique, leur permettant d'am\u00e9liorer leur qualit\u00e9 de vie. Pour PharmaMar, la soci\u00e9t\u00e9 qui fournit le m\u00e9dicament, cet essai est l'occasion de valoriser l'un de ses produits phares gr\u00e2ce \u00e0 une nouvelle application clinique.<\/span><\/p>\n

Le professeur Martin McCabe, de l'Universit\u00e9 de Manchester, investigateur principal de l'\u00e9tude, a d\u00e9clar\u00e9 :<\/span>
\"Deze samenwerking tussen het klinische onderzoeksteam, pati\u00ebntenvertegenwoordigers, financiers van de studie en PharmaMar is een geweldig voorbeeld van wat er bereikt kan worden wanneer partners met verschillende doelstellingen eerlijk en respectvol met elkaar communiceren. Ik ben verheugd dat onze gesprekken hebben geleid tot een wederzijds voordelig resultaat voor iedereen, maar met name voor pati\u00ebnten met terugkerend Ewing-sarcoom.\"<\/span><\/p>\n

\"Deze beslissing schept een belangrijk precedent voor een positieve samenwerking tussen pati\u00ebnten, artsen en de industrie\", aldus Natalia Fernandez, pati\u00ebntenbelangbehartiger. \"Het laat zien dat wanneer alle belanghebbenden samenwerken, de vooruitgang kan worden versneld voor de mensen die het het hardst nodig hebben.\"<\/span><\/p>\n

Arri\u00e8re-plan<\/span><\/strong><\/p>\n

Le sarcome d'Ewing est un cancer p\u00e9diatrique rare, avec une incidence d'environ 250 cas par an au Royaume-Uni. Les taux de survie des patients atteints de m\u00e9tastases et de rechutes sont faibles. L'essai rEECur, men\u00e9 depuis dix ans, a ouvert six bras de recherche comparant diff\u00e9rents traitements de chimioth\u00e9rapie. La trabect\u00e9dine est le premier agent utilis\u00e9 dans cet essai qui agit directement sur la fonction du g\u00e8ne de fusion EWSR1::FLI1, responsable du sarcome d'Ewing. Ce traitement pr\u00e9sente \u00e9galement l'avantage d'\u00eatre administr\u00e9 en ambulatoire et semble avoir une toxicit\u00e9 moindre que les autres traitements.<\/span><\/p>\n

L'essai rEECur recrute actuellement des participants au Royaume-Uni, en Espagne, en Italie, en Australie, en Nouvelle-Z\u00e9lande, en Suisse, au Danemark et en Autriche, et rouvrira bient\u00f4t ses portes en Finlande, en Norv\u00e8ge, en France, en Belgique et aux Pays-Bas.<\/span><\/p>\n

Source: https:\/\/www.sarcoma-patients.org\/blog\/new-study-arm-in-reecur-trial-with-trabectedin-for-relapsed-ewing-sarcoma\/<\/p>\n

i Grohar PJ, Ballman KV, Heise R, et al. SARC037: Fase II-resultaten van trabectedine toegediend als een infusie van 1 uur in combinatie met een lage dosis irinotecan bij pati\u00ebnten met recidiverend\/refractair Ewing-sarcoom. J Clin Oncol. 2024;42(16_suppl):11508. doi:10.1200\/JCO.2024.42.16_suppl.11508.<\/span><\/em><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":2086,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[172],"tags":[],"class_list":["post-2081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-wetenschap"],"yoast_head":"\nNieuwe studiearm in de rEECur-studie met trabectedine voor terugkerend Ewing-sarcoom - Cum Cura<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cumcura.be\/fr\/260130-1\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nieuwe studiearm in de rEECur-studie met trabectedine voor terugkerend Ewing-sarcoom - 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